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Sustained inflammatory insults induce cumulative DNA damage and epigenetic reprogramming, fostering malignant transformation through two synergistic mechanisms: (1) persistent immune cell activation (neutrophils, macrophages, lymphocytes) and (2) tumor co-option of inflammatory mediators (IL-6, TNF-, COX-2) as metastatic accelerants

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Expert Opin Drug Metab Toxicology (2014) 10(5):699719

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In skin treatments, it is used to reduce melanin production , which helps lighten dark spots, pigmentation, and overall skin tone

JAMA 2002;288:2015-22